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鲍精子细胞溶素(lysin)是所有动物繁殖蛋白中了解的最透彻的一种,作为一种非酶蛋白质,lysin可在卵黄膜上特异性地钻1个孔使精子从此孔进入。目前对lysin的研究主要集中在它的结构、生化、功能和进化等方面:lysin是一种由2个单体组成的二聚体分子,其单体为5个-α螺旋组成的螺旋束,lysin以二聚体形式与其糖蛋白受体(VERL)特异性结合,然后单体化,再与受体非特异性结合,这与普通动物细胞表面的分子识别的相关内容相一致;许多鲍lysin的氨基酸序列已经测定出来,并证实lysin是通过正向选择方式进化的,对于其进化的模式也有假设来说明,这对理解海洋新种的形成具有重要作用。
Abstract：Currently,abalone lysin is well known in proteins involved in animal fertilization.As a non-enzy-matic protein,lysin can create a hole for sperm to pass through the envelope surrounding the egg.The present studies have focused on its structure,biochemitry,evolution and the mechanism of action about this special pro-tein.Lysin is a dimer which is made up with two monomers,and the monomer is a five-helix bundle.A dimer of lysin binds to its glycoprotein receptor species-specifically,and then monomerizes and binds the receptor in a non-species-specific manner.This is the same as the molecular recognition between cell surfaces.The amino acid sequences of many abalone lysin have been known,and lysin evolves with high speed by positive selec-tion.There is a hypothesis to explain lysins′ rapid evolution and the evolution of species-specific fertilization.That is also important to think about how new species arise in the sea.
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基本信息:
中图分类号:S917.4
引用信息:
[1]刘慧慧,李太武.鲍精子细胞溶素研究进展[J].浙江海洋学院学报(自然科学版),2005(04):359-363.
基金信息:
浙江省自然科学基金项目(400002)
2005-12-30
2005-12-30